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The transfer function approach is widely used in classical control theory for its easy handling and physical meaning. Although the use of transfer functions is well-established for linear time-invariant systems, it is not suitable for non-stationary systems among which are sampled-data systems and processes with periodically varying coefficients. Computer-controlled continuous-time processes are a very important subset of periodic sampled-data systems which are not treatable using ordinary transfer functions.
Having established the ability of the parametric transfer function to solve this problem for single-input, single-output systems in previous work, the authors extend these methods, which incorporate time-dependence, to the idea of the parametric transfer matrix in a complete exposition of analysis and design methods for multiple-input, multiple-output (MIMO) sampled-data systems.
Multivariable Computer-controlled Systems is divided into three parts:
Appendices covering basic mathematical formulae and the description of two MATLAB(r) toolboxes round out this self-contained guide to multivariable control systems.
Of special interest to researchers in automatic control and to development engineers working with advanced control technology, Multivariable Computer-controlled Systems will also interest mathematical control theorists and graduate students studying advanced methods of computer-based control.
Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.
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